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KMID : 0359320200600010009
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Korean Journal of Veterinary Research
2020 Volume.60 No. 1 p.9 ~ p.14
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Pathological, immunohistochemical, and bacteriological findings in dogs infected with Brucella canis
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Jung Ji-Youl
Yoon Soon-Seek
Lee Seung-Hee
Park Jung-Won
Lee Jin-Ju
Her Moon
So Byung-Jae
Kim Jae-Hoon
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Abstract
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This study describes pathological, immunohistochemical, and bacteriological findings in adult dogs and fetuses naturallyinfected with Brucella (B.) canis. A total of 42 dogs including 40 dogs and 2 aborted fetuses were examined. The most common grosslesions in infected dogs were swelling of lymph nodes and spleen. The testes showed marked swelling with multifocal to diffusereddish discoloration. The most significant histopathological lesions were observed in the placenta. Placental trophoblasts weremarkedly hypertrophied due to the accumulation of intra-cellular gram-negative bacteria. Lymphocytic inflammation of varyingseverity was observed in the reproductive organs such as male testis, epididymis, and prostate gland and female uterus. Strongimmunolabelling was observed in the cytoplasm of most trophoblasts in the placental tissues using immunohistochemistry. However,immunohistochemical staining did not demonstrate any organisms in other organs of dogs and fetuses. B. canis isolates were mostfrequently obtained from the whole blood (82.5%) and superficial inguinal lymph node (77.5%) in both sexes. In addition, theisolation rate was higher in male genital organs than in those of females. Hence, management of male dogs is most important becauseinfected dogs can play a role as carriers.
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KEYWORD
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bacteriology, Brucella canis, immunohistochemistry, pathology
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